Research Focus of the Department of Pharmaceutical Sciences

The Department of Pharmaceutical Sciences excels in medicinal chemistry, focusing on heterocyclic scaffolds, pharmacophores, and rational drug design. Key research areas include thiophene, pyrimidine, imidazole, morpholine, and piperazine derivatives targeting anticancer, anti-Alzheimer, and cardiovascular therapies. Faculty also explore USFDA-approved molecules and repurposing strategies.

Herbal therapeutics and natural products form another major area, with studies on plants like Murraya koenigii, Albizzia procera, and Kigelia pinnata. Research emphasizes antioxidant, cardioprotective, antidiabetic, anticancer, and anti-inflammatory activities, along with novel herbal formulations such as orodispersible films and mucoadhesive microspheres to enhance bioavailability and efficacy.

The department advances drug delivery and pharmaceutical materials, including nanotechnology, solid dispersions, ultraflexible liposomes, cross-linked starch derivatives, and polymeric excipients. Complementary studies cover toxicology, nutraceuticals, neuroprotection, and AI-assisted drug development.

A strong focus on pharmacological research ensures in-depth evaluation of efficacy, safety, and mechanisms of synthetic and natural compounds. Faculty conduct in vivo and in vitro studies on models of hypertension, diabetes, cardiotoxicity, cancer, inflammation, and neurodegeneration, integrating toxicology and biomarker analysis for translational relevance.

 

Latest publications from department

2025 ▾
  • Thakur, S., Kumar, D., Jaiswal, S., Goel, K. K., & Pramod, R. (2025). Medicinal chemistry-based perspective on thiophene and its derivatives: Exploring the structural insights to discover plausible druggable leads. RSC Medicinal Chemistry. https://doi.org/10.1039/D4MD00450G (Impact Factor ≈ 3.7)
  • Sharma, S., Babu, M. A., Kumar, R., Singh, T. G., & Goel, K. K. (2025). A review on pyrimidine-based pharmacophore as a template for the development of hybrid drugs with anticancer potential. Molecular Diversity. https://doi.org/10.1007/s11030-025-11112 (≈ 2.7)
  • Gupta, S., Babu, M. A., Kumar, R., Singh, T. G., & Goel, K. K. (2025). Exploring USFDA-approved imidazole-based small molecules in drug discovery: A mini perspective. Chemistry & Biodiversity. https://doi.org/10.1002/cbdv.202403020 (≈ 2.3)
  • Kumar, R., Kumar, N., Maparu, K., Singh, S., Rajput, S. K., Kumar, A., … (2025). Pharmacological evaluation of Kigelia pinnata root bark ethanolic extract in DOCA salt-induced hypertension in experimental rats. Journal of Biologically Active Products from Nature, 15(2), 196–209.
  • Goel, K. K., Lakhanpal, S., Kumar, R., Prasad, K. N., Dhiman, S., & Kumar, G. (2025). Thieno[3,2-b]pyrrole as a privileged scaffold in medicinal chemistry: An exploration of synthetic strategies and anticancer attributes. Journal of Molecular Structure, 1321(1), 139654. (≈ 3.6)
  • Goel, K. K., Singhal, P., Babu, M. A., Pandey, S. K., Tyagi, Y., & Kumar, R. (2025). A mini-review on morpholine-ring-containing US FDA-approved drugs: A medicinal chemistry-based analysis from 2013 to 2023. Synlett. (≈ 2.7)
  • Goel, K. K., Singhal, P., Babu, M. A., Kumar, S., & others. (2025). A decade of piperazine-based small molecules approved by USFDA: Exploring the medicinal chemistry impact of this versatile pharmacophore. Synlett. https://doi.org/10.1055/a-2508-9961 (≈ 2.7)
  • Singhal, P., & Thapliyal, S. (2025). Benefits of garlic in cardiovascular. In Nutraceuticals in Cardiac Health Management.
  • Srivastava, V., Khatoon, B., Upadhyay, U., & Singhal, P. (2025). Evaluation of cardioprotective effect of daidzein in 5-fluorouracil-induced cardiotoxicity in Wistar rats. Indian Drugs, 62(4).
  • Kumar, V., Tanwar, N., Goel, M., Khan, M., Kumar, D., Singh, G., Mundlia, J., & Kumar, A. (2025). Antioxidants for skin health. Recent Advances in Food, Nutrition & Agriculture, 16(3), 250–265.
  • Dobhal, V., Kumar, A., Garg, I., Kumar, A., & Goel, F. (2025). Strabismus and nystagmus in oculocutaneous albinism: Clinical perspectives, diagnosis, and role of neurotransmitters. Neurogenetics, 26(1), 50.
  • Bansal, A., & Goel, N. (2025). Development and evaluation of herbal mouthwash for oral hygiene: A “Herbal Bliss.” International Journal of Novel Research and Development, 10(6).
  • Boddu, V. S., Kumar, H., & Rawat, B. S. (2025). Solid dispersions: A comprehensive tool for overcoming poor drug solubility. Asian Journal of Pharmaceutical Education and Research, 14(3), 43–61.
  • Balkrishna, A., Singh, S., Mishra, S., Rana, M., Mishra, R. K., Rajput, S. K., & Arya, V. (2025). Impact of biosensors and biomarkers in diabetes care: A review. Biomedical Materials & Devices, 3(2), 835–851.
  • Gawali, B., Shrivastava, S., Kumar, R. U., Rajput, S. K., & Jeengar, M. K. (2025). Exploring small molecule inhibitors in cardiovascular and cerebrovascular diseases. Frontiers in Pharmacology, 16, 1559488.
  • Singh, S., Arya, V., Mishra, R. K., & Rajput, S. K. (2025). Clinical efficacy of yoga practices in the management of polycystic ovarian syndrome: Insights from a single-arm pilot trial.
  • Rajput, S. K., & Singh, S. (2025). The influence of alkylating agent on environment: Cyclophosphamide. In Hazardous Chemicals (pp. 629–643).
  • Rajput, S. K., Singh, S., & Bhardwaj, R. (2025). Toluene toxicity: Outline, management, and prognosis. In Hazardous Chemicals (pp. 391–404).
  • Rajput, S. K., Bhardwaj, R., Madan, S., & Singh, R. (2025). Ethylene glycol: Industrial application and risk assessment. In Hazardous Chemicals (pp. 205–217).
  • Singh, S., & Rajput, S. K. (2025). A review on the toxicology of white spirit. In Hazardous Chemicals (pp. 349–360).
2024 ▾
  • Chahal, J. S., Rani, P., Shweta, S., Goel, K. K., Joshi, G., & others. (2024). Pyrano[2,3-c]pyrazole fused spirooxindole-linked 1,2,3-triazoles as antioxidant agents: Exploring their utility in antidiabetic drug development. Bioorganic Chemistry, 147, 107363. (≈ 5.4)
  • Mehta, V., Dwivedi, A. R., Ludhiadch, A., Rana, V., Goel, K. K., Uniyal, P., & Joshi, G. (2024). A decade of USFDA-approved small molecules as anti-inflammatory agents: Recent trends and commentaries on the industrial perspective. European Journal of Medicinal Chemistry, 263, 115942. (≈ 7.1)
  • Goel, K. K., Rawat, P., Murti, Y., Mahajan, S., & Mahajan, H. S. (2024). Investigating therapies targeting druggable targets of mitochondria: Exploring efficacy for cancer treatment. ChemistrySelect, 9(34), e202401707. (≈ 1.9)
  • Goel, K. K., Chahal, S., Kumar, D., Jaiswal, S., & Kumar, N. (2024). Repurposing of USFDA-approved drugs to identify lead for inhibition of acetylcholinesterase enzyme: A plausible utility as an anti-Alzheimer agent. RSC Medicinal Chemistry. https://doi.org/10.1039/D4MD00461B (≈ 3.7)
  • Goel, K. K., Thapliyal, S., Vishnoi, R., Murti, Y., Kumar, R., & Chavan, N. (2024). Exploring anticancer properties of phytoconstituents and comparative analysis with USFDA-approved synthetic anticancer agents. Chemical Biology & Drug Design, 103, e14561. (≈ 3.4)
  • Bhatt, P., Singh, S., Kumar, V., Nagarajan, K., Mishra, S. K., Dixit, P. K., … Kumar, V. (2024). Artificial intelligence in pharmaceutical industry: Revolutionizing drug development and delivery. Current Artificial Intelligence, 2(1), E051223224198.
  • Singh, S., Bhatt, P., Kumar, V., & Singh, N. P. (2024). Phytonutrients, anthocyanidins, and anthocyanins: Dietary and medicinal pigments with possible health benefits. In Advances in Flavonoids for Human Health and Prevention of Diseases (pp. 23–46).
  • … (other 2024 entries as provided)
2023 ▾
  • Goel, K. K., Thapliyal, S., Kharb, R., Joshi, G., Negi, A., & Kumar, B. (2023). Imidazoles as serotonin receptor modulators for treatment of depression: Structure–activity relationship studies. Pharmaceutics, 15(9), 2208. (≈ 6.2)
  • Goel, K. K., Hussain, A., Altamimi, M. A., Rajput, S. K., Sharma, P. P., & Kharb, R. (2023). Identification of potential antitubulin agents with anticancer assets from imidazo[1,2-a]quinoxaline derivatives: In silico and in vitro approaches. Molecules, 28(2), 802. (≈ 4.6)
  • Laasya, G., Thapliyal, S., Goel, K. K., Kumar, B., Poduri, R., & Joshi, G. (2023). Phytochemical analysis and HPTLC-guided quantification of Boeravinone B from Boerhaavia diffusa root extracts. Separation Science Plus, 2300140. (≈ 2.1)
  • … (other 2023 entries as provided)
2022 ▾
  • Goel, K. K., Rajput, S. K., Kumar, A., Nandi, N. K., Joshi, G., & Kharb, R. (2022). Imidazoquinoxaline as a privileged fused pharmacophore in anticancer drug development: A review of synthetic strategies and medicinal aspects. ChemistrySelect, 7(37), e202200834.
  • Singh, A., Kumar, V., Kumar, A., Srivastava, M., Mathur, P., & Bhalla, R. (2022). Assessment of the current prescribing practices and incidences of prescription error in a tertiary care hospital. Journal of Pharmaceutical Negative Results, 13.
  • … (other 2022 entries as provided)
2021 ▾
  • Sapra, A. J. K., Sapra, A., Sharma, R., Kakkar, S., & Bajaj, R. (2021). Ayurveda: A boon in pandemics. Asian Pacific Journal of Health Sciences, 8(4), 205–208.
  • Tyagi, N., Kumar, A., & Verma, S. (2021). Thin layer chromatography of Solanum xanthocarpum Schard. Wendl. (ethanolic, hydroalcoholic and aqueous extracts). Annals of the Romanian Society for Cell Biology, 25(7).

Thrust Research Areas

PHARMACEUTICS

  • NANOTECHNOLOGY
  • PHARMACOVIGILANCE
  • HERBALS COSMETICS

NOVEL DRUG DELIVERY SYSTEM

  • Advanced Drug Delivery System
  • Controlled Drug Delivery System
  • Modulated Drug Delivery System
  • Targeted Drug Delivery System
  • Transdermal Drug Delivery System.

PHARMACEUTICAL CHEMISTRY

  • Natural, Semi-Synthetic and Synthetic Chemistry
  • Instrumental Techniques
  • Analytical Method Development
  • Analytical Method Validation

PHARMACOLOGY

  • Antifertility
  • Anti-Obesity
  • Cancer Genetics & Cell Signaling
  • Cancer Immunology
  • Cardiovascular Disorders
  • CNS Disorders
  • Diabetes Mellitus
  • Drug Addiction
  • pilepsy
  • Immunopharmacology
  • Infertility

PHARMACOGNOSY

  • Delivery of Herbs
  • Complementary and Alternative Medicine
  • Isolation & Characterization of Phytocostituents
  • Characterization of Phytocostituents
  • Phytochemical Investigation of Herbal Formulations
  • Standardization & Isolation

DRUG REGULATORY AFFAIRS

CLINICAL RESEARCH

Funded Projects

Research Projects [Completed/ Ongoing]

Principal Investigator Title of research project Funding agency Amount in lakh
Dr. Vipin Kumar  Applicability of extracted resistant starch from madua grains in indigenous and chemically modified form in development of drug delivery devices (P.I.) Uttarakhand State Council for Science & Technology, Dehradun Rs. 3.67
Dr. Prince Prashant Sharma Synthesis, development and biochemical activities of some novel microtubule-disrupting quinazolinyl-amines as antiproliferative agents SERB, DST, New Delhi Rs.23.56

Patent filled/Published/Granted

Name of applicants Patent Status
PRINCE PRASHANT SHARMA N4-(6,7,8-TRIMETHOXYQUINAZOLIN-4-YL)BIPHENYL-4,4′-DIAMINE AS AN ANTICANCER AGENT Granted

Publication Recent (From the database of faculties)

S.No. Faculty Google Scholar Data
1. Prof. S. K. Rajput View
2. Dr. Vipin Kumar Sharma View
3. Mr. Kapil Kumar Goel View
4. Mr. Vinod Nautiyal View
5. Dr. Ashwani Kumar Jangra View
6. Dr. Prince Prashant Sharma View
7. Mr. Ashish Pandey View
8. Mr. Ravi Pratap View
9. Mr. Balwant singh Rawat View
10. Mr. Rajendra Yadav View
11. Mr. Deepak Singh Negi View
12. Dr. Peeush Singhal View
13. Dr. Abhishek Bansal View
14. Mr. Ravindra Kumar View
15. Mr. Rahul Kumar View
16. Dr. Naresh Kumar Rangra View

Departmental Research Profile

pharmaresearchprofile